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Discrimination between Hard Metals with Soft Ligand Donor Atoms: An On‐Fluorescence Probe for Manganese(II)
Author(s) -
Liang Jian,
Canary James W.
Publication year - 2010
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201002853
Subject(s) - fluorophore , manganese , fluorescence , ligand (biochemistry) , selectivity , chemistry , receptor , physics , optics , catalysis , biochemistry , organic chemistry
A backwards strategy for achieving Mn 2+ /Ca 2+ selectivity was demonstrated: Instead of optimizing binding of Mn 2+ , the bapta ligand (upper structure in scheme) was modified by changing O to N donors to discourage association by unwanted competitor Ca 2+ . Attachment of a fluorophore gave a Mn 2+ ‐selective on‐fluorescent probe for use in live cell imaging.