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Dynamic Peptides as Biomimetic Carbohydrate Receptors
Author(s) -
Rauschenberg Melanie,
Bomke Susanne,
Karst Uwe,
Ravoo Bart Jan
Publication year - 2010
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201002847
Subject(s) - haystack , receptor , cyclic peptide , chemistry , disulfide bond , biochemistry , peptide , combinatorial chemistry , stereochemistry , computer science , world wide web
Finding the needle in the haystack: A dynamic combinatorial library (DCL) of peptides was created using the disulfide‐exchange reaction of cysteines. Three cyclic peptides were found to be selective receptors for carbohydrates in water. One of these, HisHis, formed preferentially in a DCL in the presence of the neurotransmitter NANA.