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Photochemical Reactions as Key Steps in Natural Product Synthesis
Author(s) -
Bach Thorsten,
Hehn Jörg P.
Publication year - 2011
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201002845
Subject(s) - natural product , chemistry , key (lock) , photochemistry , stereoselectivity , molecule , natural (archaeology) , carbon fibers , combinatorial chemistry , organic chemistry , computer science , catalysis , computer security , archaeology , algorithm , composite number , history
Photochemical reactions contribute in a significant way to the existing repertoire of carbon–carbon bond‐forming reactions by allowing access to exceptional molecular structures that cannot be obtained by conventional means. In this Review, the most important photochemical transformations that have been employed in natural product synthesis are presented. Selected total syntheses are discussed as examples, with particular attention given to the photochemical key step and its stereoselectivity. The structural relationship between the photochemically generated molecule and the natural product is shown, and, where necessary, the consecutive reactions in the synthesis are illustrated and classified.