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Multifunctional Gold Nanoshells on Silica Nanorattles: A Platform for the Combination of Photothermal Therapy and Chemotherapy with Low Systemic Toxicity
Author(s) -
Liu Huiyu,
Chen Dong,
Li Linlin,
Liu Tianlong,
Tan Longfei,
Wu Xiaoli,
Tang Fangqiong
Publication year - 2011
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201002820
Subject(s) - photothermal therapy , polyethylene glycol , nanoshell , toxicity , nanotechnology , magic bullet , colloidal gold , chemistry , materials science , nanoparticle , bioinformatics , organic chemistry , biology
Magic bullets : A drug‐loaded structure comprising a PEGylated (PEG=polyethylene glycol) gold nanoshell on silica nanorattle spheres (GSNs; see picture) combines remote‐controlled photothermal therapy with chemotherapy. Tumor cells are killed with higher efficacy and less toxicity than the free drug.