Multifunctional Gold Nanoshells on Silica Nanorattles: A Platform for the Combination of Photothermal Therapy and Chemotherapy with Low Systemic Toxicity | Zendy

Liu Huiyu | Zendy; Chen Dong | Zendy; Li Linlin | Zendy; Liu Tianlong | Zendy; Tan Longfei | Zendy; Wu Xiaoli | Zendy; Tang Fangqiong | Zendy

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Multifunctional Gold Nanoshells on Silica Nanorattles: A Platform for the Combination of Photothermal Therapy and Chemotherapy with Low Systemic Toxicity

Author(s) -

Liu Huiyu,

Chen Dong,

Li Linlin,

Liu Tianlong,

Tan Longfei,

Wu Xiaoli,

Tang Fangqiong

Publication year - 2011

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.201002820

Subject(s) - photothermal therapy , polyethylene glycol , nanoshell , toxicity , nanotechnology , magic bullet , colloidal gold , chemistry , materials science , nanoparticle , bioinformatics , organic chemistry , biology

Magic bullets : A drug‐loaded structure comprising a PEGylated (PEG=polyethylene glycol) gold nanoshell on silica nanorattle spheres (GSNs; see picture) combines remote‐controlled photothermal therapy with chemotherapy. Tumor cells are killed with higher efficacy and less toxicity than the free drug.

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