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Glycosidase Inhibition with Fullerene Iminosugar Balls: A Dramatic Multivalent Effect
Author(s) -
Compain Philippe,
Decroocq Camille,
Iehl Julien,
Holler Michel,
Hazelard Damien,
Mena Barragán Teresa,
Ortiz Mellet Carmen,
Nierengarten JeanFrançois
Publication year - 2010
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201002802
Subject(s) - iminosugar , glycoside hydrolase , chemistry , stereochemistry , biophysics , biochemistry , enzyme , biology
Superball! A dodecavalent iminosugar derivative with a fullerene core (see picture) shows a binding enhancement of up to three orders of magnitude over the corresponding monovalent ligand in glycosidase inhibition assays. This is the first evidence of a significant multivalent effect in glycosidase inhibition.
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