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Cross‐Coupling in a Flow Microreactor: Space Integration of Lithiation and Murahashi Coupling
Author(s) -
Nagaki Aiichiro,
Kenmoku Akira,
Moriwaki Yuya,
Hayashi Atsushi,
Yoshida Junichi
Publication year - 2010
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201002763
Subject(s) - microreactor , coupling (piping) , ligand (biochemistry) , flow (mathematics) , space (punctuation) , aryl , computer science , carbene , combinatorial chemistry , flow chemistry , chemistry , catalysis , physics , organic chemistry , engineering , mechanical engineering , mechanics , operating system , biochemistry , receptor , alkyl
Going with the flow : The use of palladium catalysts bearing a carbene ligand resulted in a faster Murahashi coupling, and enabled its integration with the Br–Li exchange of ArBr with BuLi in a microreactor (see picture). This system allows the cross‐coupling of two different aryl bromides within a minute without necessitating low temperatures (−78°C).