Cross‐Coupling in a Flow Microreactor: Space Integration of Lithiation and Murahashi Coupling | Zendy

Nagaki Aiichiro | Zendy; Kenmoku Akira | Zendy; Moriwaki Yuya | Zendy; Hayashi Atsushi | Zendy; Yoshida Junichi | Zendy

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Cross‐Coupling in a Flow Microreactor: Space Integration of Lithiation and Murahashi Coupling

Author(s) -

Nagaki Aiichiro,

Kenmoku Akira,

Moriwaki Yuya,

Hayashi Atsushi,

Yoshida Junichi

Publication year - 2010

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.201002763

Subject(s) - microreactor , coupling (piping) , ligand (biochemistry) , flow (mathematics) , space (punctuation) , aryl , computer science , carbene , combinatorial chemistry , flow chemistry , chemistry , catalysis , physics , organic chemistry , engineering , mechanical engineering , mechanics , operating system , biochemistry , receptor , alkyl

Going with the flow : The use of palladium catalysts bearing a carbene ligand resulted in a faster Murahashi coupling, and enabled its integration with the Br–Li exchange of ArBr with BuLi in a microreactor (see picture). This system allows the cross‐coupling of two different aryl bromides within a minute without necessitating low temperatures (−78°C).

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