Premium
An Inhibitor of a Cell Adhesion Receptor Stimulates Cell Migration
Author(s) -
Shabbir Shagufta H.,
Eisenberg Jessica L.,
Mrksich Milan
Publication year - 2010
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201002699
Subject(s) - microbiology and biotechnology , cell migration , cell adhesion , chemistry , receptor , cell , biology , biochemistry
Making cells get a move on : The integrins are cell‐surface receptors that mediate the adhesion and migration of cells on a protein matrix. An open question is whether addition of an inhibitor of the receptor slows or accelerates cell migration. By using self‐assembled monolayers presenting a cell adhesion ligand as a model system it is found that an inhibitor (RGD peptide) can stimulate cell migration.