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[4+2] Cycloaddition Reaction of Cyclic Alkyne–{Co 2 (CO) 6 } Complexes with Dienes
Author(s) -
Iwasawa Nobuharu,
Ooi Isao,
Inaba Kennichi,
Takaya Jun
Publication year - 2010
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201002683
Subject(s) - cycloaddition , alkyne , chemistry , medicinal chemistry , benzoquinone , transformation (genetics) , combinatorial chemistry , photochemistry , organic chemistry , catalysis , biochemistry , gene
A general protocol for the title transformation has been achieved and is applicable to a wide range of acyclic 1,3‐dienes and cyclic alkyne—{Co 2 (CO) 6 } complexes leading to various types of benzannulated medium‐sized cyclic compounds after oxidative work up (see scheme; DDQ=2,3‐dichloro‐5,6‐dicyano‐1,4‐benzoquinone). Interestingly, the [4+2] cycloaddition proceeded preferentially over the Pauson–Khand reaction.
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