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Cover Picture: Design and Folding of [Glu A4 (O β Thr B30 )]Insulin (“Ester Insulin”): A Minimal Proinsulin Surrogate that Can Be Chemically Converted into Human Insulin (Angew. Chem. Int. Ed. 32/2010)
Author(s) -
Sohma Youhei,
Hua QingXin,
Whittaker Jonathan,
Weiss Michael A.,
Kent Stephen B. H.
Publication year - 2010
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201002659
Subject(s) - proinsulin , insulin , human insulin , medicine , chemistry , endocrinology
The efficient total chemical synthesis … … of insulin has been a challenge for more than 40 years. In their Communication on page 5489 ff., Y. Sohma, S. B. H. Kent, and co‐workers show that a ‘zero length’ ester‐linked precursor folds as efficiently as full length proinsulin and can be simply converted into fully active insulin by saponification. (The artwork for the cover picture was prepared by D. Kent and is based on a concept by Y. Sohma).