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Intracellular pH‐Responsive Mesoporous Silica Nanoparticles for the Controlled Release of Anticancer Chemotherapeutics
Author(s) -
Lee ChiaHung,
Cheng ShihHsun,
Huang IPing,
Souris Jeffrey S.,
Yang ChungShi,
Mou ChungYuan,
Lo LeuWei
Publication year - 2010
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201002639
Subject(s) - mesoporous silica , hydrazone , intracellular , doxorubicin , endosome , chemistry , nanoparticle , cancer cell , hydrolysis , biophysics , apoptosis , mesoporous material , nanotechnology , combinatorial chemistry , biochemistry , materials science , stereochemistry , cancer , chemotherapy , biology , catalysis , genetics
Cut here to cure : Doxorubicin attached to pH‐sensitive mesoporous silica nanoparticles (MSN‐hydrazone‐Dox) shows potential in the chemotherapeutic treatment of liver cancer. Hydrolysis of the pH‐sensitive hydrazone bond in the acidic environment of endosomes/lysosomes (see picture) releases Dox intracellularly from the MSN nanochannels, resulting in highly efficient apoptotic cell death.