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Conformations of γ‐Aminobutyric Acid (GABA): The Role of the n→π* Interaction
Author(s) -
Blanco Susana,
López Juan C.,
Mata Santiago,
Alonso José L.
Publication year - 2010
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201002535
Subject(s) - conformational isomerism , trajectory , computer science , chemistry , neuroscience , psychology , physics , molecule , organic chemistry , astronomy
Conformation confirmation : The nine conformers of the neurotransmitter γ‐aminobutyric acid (GABA) identified in the gas phase can serve as a basis to represent the shape of GABA. An n→π* interaction guided by the Bürgi–Dunitz trajectory of nucleophilic addition is thought to be relevant in the stabilization of two of the folded conformers ( gG1 and gG3 in the picture).