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Efficient Synthesis of Pyrazoles: Oxidative CC/NN Bond‐Formation Cascade
Author(s) -
Neumann Julia J.,
Suri Mamta,
Glorius Frank
Publication year - 2010
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201002389
Subject(s) - cascade , hydrazine (antidepressant) , chemistry , combinatorial chemistry , computer science , bond , section (typography) , business , finance , operating system , chromatography
Golden section : A novel synthetic strategy for the synthesis of tetrasubstituted pyrazoles is provided. In an efficient CC/NN bond‐formation cascade, enamines and nitriles are oxidatively coupled to deliver pyrazoles in good yields (see scheme). The ready availability of the starting materials, the high level of practicability of the reaction and work up, and the avoidance of hydrazine starting materials make the method attractive.