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Catalytic Organometallic Reactions of Ammonia
Author(s) -
Klinkenberg Jessica L.,
Hartwig John F.
Publication year - 2011
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201002354
Subject(s) - amination , hydroamination , catalysis , chemistry , ammonia , alkylation , homogeneous , allylic rearrangement , organic chemistry , combinatorial chemistry , coupling reaction , selectivity , homogeneous catalysis , physics , thermodynamics
Until recently, ammonia had rarely succumbed to catalytic transformations with homogeneous catalysts, and the development of such reactions that are selective for the formation of single products under mild conditions has encountered numerous challenges. However, recently developed catalysts have allowed several classes of reactions to create products with nitrogen‐containing functional groups from ammonia. These reactions include hydroaminomethylation, reductive amination, alkylation, allylic substitution, hydroamination, and cross‐coupling. This Minireview describes examples of these processes and the factors that control catalyst activity and selectivity.