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Palladium‐Catalyzed γ‐Arylation of α,β‐Unsaturated Esters from Silyl Ketene Acetals
Author(s) -
Huang David S.,
Hartwig John F
Publication year - 2010
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201002328
Subject(s) - ketene , chemistry , silylation , palladium , library science , catalysis , medicinal chemistry , organic chemistry , computer science
Smarty cat : A method for the palladium‐catalyzed γ‐arylation of α,β‐unsaturated esters via silyl ketene acetals in the absence of fluoride has been developed. The coupling proceeds with electron‐rich and electron‐poor aryl bromides and vinyl bromides in high yields with a high tolerance for other functional groups.