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Chiral Ammonium Betaines as Ionic Nucleophilic Catalysts
Author(s) -
Uraguchi Daisuke,
Koshimoto Kyohei,
Miyake Shuhei,
Ooi Takashi
Publication year - 2010
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201002315
Subject(s) - betaine , catalysis , nucleophile , ionic liquid , chemistry , substrate (aquarium) , molecular sieve , ionic bonding , ammonium , combinatorial chemistry , medicinal chemistry , enantioselective synthesis , organic chemistry , ion , biology , ecology
Catalyst debut : The chiral ammonium betaine 1 has been successfully applied to the asymmetric Steglich rearrangement as an ionic nucleophilic catalyst. The catalyzed reaction results in record levels of product enantioselectivity, and has a broad substrate scope. M.S.=molecular sieves, Troc=2,2,2‐trichloroethoxycarbonyl.