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Radiosynthesis and Evaluation of [ 18 F]Selectfluor bis(triflate)
Author(s) -
Teare Harriet,
Robins Edward G.,
Kirjavainen Anna,
Forsback Sarita,
Sandford Graham,
Solin Olof,
Luthra Sajinder K.,
Gouverneur Véronique
Publication year - 2010
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201002310
Subject(s) - selectfluor , trifluoromethanesulfonate , reagent , electrophile , chemistry , combinatorial chemistry , organic chemistry , catalysis
Selectfluor, one of the most reactive and commonly used electrophilic fluorinating N–F reagents, has been radiolabeled with 18 F. The resulting new [ 18 F]‐labeled N–F reagent is safe, nontoxic, and easy to handle. The combined use of [ 18 F]Selectfluor bis(triflate) and AgOTf allows for the preparation of electron‐rich 18 F‐aromatic compounds through a simple “shake and mix” protocol at room temperature (see scheme; SA=specific activtiy).