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Cover Picture: Identification and Structure of Small‐Molecule Stabilizers of 14 – 3 – 3 Protein–Protein Interactions (Angew. Chem. Int. Ed. 24/2010)
Author(s) -
Rose Rolf,
Erdmann Silke,
Bovens Stefanie,
Wolf Alexander,
Rose Micheline,
Hennig Sven,
Waldmann Herbert,
Ottmann Christian
Publication year - 2010
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201002255
Subject(s) - fusicoccin , wilting , small molecule , chemistry , molecule , biophysics , stereochemistry , crystallography , protein structure , biochemistry , biology , botany , atpase , organic chemistry , enzyme
Fusicoccin , a naturally occurring compound, stabilizes a 14‐3‐3 protein–protein interaction and induces wilting of plants by opening the gas‐exchanging stomatal pores (gray). C. Ottmann and co‐workers describe in their Communication on page 4129 ff. how easily available small molecules have been identified that mimic the action of fusicoccin. Crystal‐structure and functional biophysical analyses reveal the binding modes of these molecules.