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Light‐Induced Control of Protein Translocation by the SecYEG Complex
Author(s) -
Bonardi Francesco,
London Gábor,
Nouwen Nico,
Feringa Ben L.,
Driessen Arnold J. M.
Publication year - 2010
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201002243
Subject(s) - photoswitch , azobenzene , transmembrane protein , closure (psychology) , chemistry , biophysics , nanotechnology , computer science , optoelectronics , materials science , biology , biochemistry , photochemistry , receptor , organic chemistry , molecule , economics , market economy
Please close the pore! An organochemical photoswitch was introduced into two transmembrane segments that comprise the lateral gate of the bacterial‐membrane‐embedded protein‐conducting pore. Reversible switching of the azobenzene between the trans and cis configurations by irradiation with visible and UV light enforced the opening and closure of the protein‐conducting pore (see scheme).