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Total Synthesis of (−)‐Virginiamycin M 2
Author(s) -
Wu Jie,
Panek James S.
Publication year - 2010
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201002220
Subject(s) - virginiamycin , ring (chemistry) , modular design , total synthesis , chemistry , stereochemistry , antibiotics , computer science , organic chemistry , biochemistry , programming language
Has a nice ring to it : A concise and modular total synthesis of the naturally occurring antibiotic virginiamycin M 2 is described. A Barbier‐type cyclization was used to close the 23‐membered macrocycle and deliver virginiamycin M 2 in 19 steps from a chiral organosilane.