1,2,3‐Trisubstituted Indanes by Highly Diastereoselective Palladium‐Catalyzed Oxyarylation of Indenes with Arylboronic Acids and Nitroxides | Zendy

Kirchberg Sylvia | Zendy; Fröhlich Roland | Zendy; Studer Armido | Zendy

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1,2,3‐Trisubstituted Indanes by Highly Diastereoselective Palladium‐Catalyzed Oxyarylation of Indenes with Arylboronic Acids and Nitroxides

Author(s) -

Kirchberg Sylvia,

Fröhlich Roland,

Studer Armido

Publication year - 2010

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.201002214

Subject(s) - catalysis , chemistry , stereoselectivity , palladium , combinatorial chemistry , reaction conditions , organic chemistry

Excellent stereoselectivity is obtained in the synthesis of biologically interesting 1,2,3‐trisubstituted indanes B by the reaction of readily prepared 3‐substituted indenes A with commercially available arylboronic acids by using various TEMPO derivatives as external oxidants and Pd(OAc) 2 as a catalyst. The anti , anti isomers are formed and reactions occur stereospecifically under mild conditions.

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