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1,2,3‐Trisubstituted Indanes by Highly Diastereoselective Palladium‐Catalyzed Oxyarylation of Indenes with Arylboronic Acids and Nitroxides
Author(s) -
Kirchberg Sylvia,
Fröhlich Roland,
Studer Armido
Publication year - 2010
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201002214
Subject(s) - catalysis , chemistry , stereoselectivity , palladium , combinatorial chemistry , reaction conditions , organic chemistry
Excellent stereoselectivity is obtained in the synthesis of biologically interesting 1,2,3‐trisubstituted indanes B by the reaction of readily prepared 3‐substituted indenes A with commercially available arylboronic acids by using various TEMPO derivatives as external oxidants and Pd(OAc) 2 as a catalyst. The anti , anti isomers are formed and reactions occur stereospecifically under mild conditions.