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An Unexpected Example of Protein‐Templated Click Chemistry
Author(s) -
Suzuki Takayoshi,
Ota Yosuke,
Kasuya Yuki,
Mutsuga Motoh,
Kawamura Yoko,
Tsumoto Hiroki,
Nakagawa Hidehiko,
Finn M. G.,
Miyata Naoki
Publication year - 2010
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201002205
Subject(s) - click chemistry , cycloaddition , azide , chemistry , triazole , alkyne , histone deacetylase , computer science , combinatorial chemistry , catalysis , biochemistry , organic chemistry , histone , gene
It all happened with a click : In a search for histone deacetylase (HDAC) inhibitors using in situ click chemistry, the first example of protein–Cu acceleration of the azide–alkyne cycloaddition reaction was uncovered. The copper center in the protein target HDAC8 catalyzed triazole formation between one azide–alkyne pair among 30 possibilities. These results provide a new route to HDAC inhibitors and a precedent for new types of protein‐based catalysts for click chemistry.