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Cover Picture: Which Is the Actual Catalyst: Chiral Phosphoric Acid or Chiral Calcium Phosphate? (Angew. Chem. Int. Ed. 22/2010)
Author(s) -
Hatano Manabu,
Moriyama Katsuhiko,
Maki Toshikatsu,
Ishihara Kazuaki
Publication year - 2010
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201002202
Subject(s) - phosphoric acid , catalysis , enantioselective synthesis , phosphate , chemistry , calcium , organocatalysis , stereoselectivity , optically active , organic chemistry
Both are active , the chiral phosphoric acid and the chiral calcium phosphate. K. Ishihara and co‐workers describe in their Communication on page 3823 ff. a highly enantioselective direct Mannich‐type reaction of aldimines with a wide range of 1,3‐dicarbonyl compounds. The catalyst, a chiral phosphoric acid, is used in the presence or absence of Ca II . The absolute stereoselectivity of the products without Ca II is the opposite of that obtained with the calcium phosphate catalyst.