Identification of Thiazolidinones Spiro‐Fused to Indolin‐2‐ones as Potent and Selective Inhibitors of the  Mycobacterium tuberculosis  Protein Tyrosine Phosphatase B | Zendy

Vintonyak Viktor V. | Zendy; Warburg Karin | Zendy; Kruse Holger | Zendy; Grimme Stefan | Zendy; Hübel Katja | Zendy; Rauh Daniel | Zendy; Waldmann Herbert | Zendy

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Identification of Thiazolidinones Spiro‐Fused to Indolin‐2‐ones as Potent and Selective Inhibitors of the Mycobacterium tuberculosis Protein Tyrosine Phosphatase B

Author(s) -

Vintonyak Viktor V.,

Warburg Karin,

Kruse Holger,

Grimme Stefan,

Hübel Katja,

Rauh Daniel,

Waldmann Herbert

Publication year - 2010

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.201002138

Subject(s) - mycobacterium tuberculosis , identification (biology) , key (lock) , computational biology , tuberculosis , protein tyrosine phosphatase , chemistry , biochemistry , computer science , stereochemistry , information retrieval , tyrosine , combinatorial chemistry , biology , medicine , botany , computer security , pathology

The best of 40 000 : Detailed structure–activity‐relationship studies revealed key structural elements of indolin‐2‐on‐3‐spirothiazolidinones (see example) and their appropriate configuration for strong inhibitory activity against the pathophysiologically relevant title protein.

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