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Identification of Thiazolidinones Spiro‐Fused to Indolin‐2‐ones as Potent and Selective Inhibitors of the Mycobacterium tuberculosis Protein Tyrosine Phosphatase B
Author(s) -
Vintonyak Viktor V.,
Warburg Karin,
Kruse Holger,
Grimme Stefan,
Hübel Katja,
Rauh Daniel,
Waldmann Herbert
Publication year - 2010
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201002138
Subject(s) - mycobacterium tuberculosis , identification (biology) , key (lock) , computational biology , tuberculosis , protein tyrosine phosphatase , chemistry , biochemistry , computer science , stereochemistry , information retrieval , tyrosine , combinatorial chemistry , biology , medicine , botany , computer security , pathology
The best of 40 000 : Detailed structure–activity‐relationship studies revealed key structural elements of indolin‐2‐on‐3‐spirothiazolidinones (see example) and their appropriate configuration for strong inhibitory activity against the pathophysiologically relevant title protein.