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Zinc Chloride Enhanced Arylations of Secondary Benzyl Trifluoroacetates in the Presence of β‐Hydrogen Atoms
Author(s) -
Duan Hui,
Meng Lingkui,
Bao Denghui,
Zhang Heng,
Li Yao,
Lei Aiwen
Publication year - 2010
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201002116
Subject(s) - zinc , reagent , chemistry , hydrogen , combinatorial chemistry , chloride , benzyl chloride , organic chemistry , inorganic chemistry , catalysis
Zinc or swim : Arylation of benzyl trifluoroacetates with arylzinc reagents in the presence of β‐hydrogen atoms were realized under mild conditions. Both electron‐rich and electron‐deficient arene substrates were successfully arylated. This arylation method could offer a very versatile synthetic route to access a series of diversity‐oriented diarylalkane motifs. TFA = trifluoroacetyl.