Enantioselective Oxidative Cross‐Coupling Reaction of 3‐Indolylmethyl CH Bonds with 1,3‐Dicarbonyls Using a Chiral Lewis Acid‐Bonded Nucleophile to Control Stereochemistry | Zendy

Guo Chang | Zendy; Song Jin | Zendy; Luo ShiWei | Zendy; Gong LiuZhu | Zendy

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Enantioselective Oxidative Cross‐Coupling Reaction of 3‐Indolylmethyl CH Bonds with 1,3‐Dicarbonyls Using a Chiral Lewis Acid‐Bonded Nucleophile to Control Stereochemistry

Author(s) -

Guo Chang,

Song Jin,

Luo ShiWei,

Gong LiuZhu

Publication year - 2010

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.201002108

Subject(s) - enantioselective synthesis , trifluoromethanesulfonate , lewis acids and bases , nucleophile , chemistry , malonate , chiral lewis acid , indole test , combinatorial chemistry , medicinal chemistry , organic chemistry , stereochemistry , catalysis

A highly enantioselective CH‐activation‐based oxidative coupling reaction of 3‐arylmethylindole derivatives with dibenzyl malonate by using chiral Lewis acid bonded nucleophiles provided an approach to indole derivatives (see scheme; DDQ=2,3‐dichloro‐5,6‐dicyano‐1,4‐benzoquinone, OTf=trifluoromethanesulfonate).

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