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Constructing Multiply Substituted Arenes Using Sequential Palladium(II)‐Catalyzed CH Olefination
Author(s) -
Engle Keary M.,
Wang DongHui,
Yu JinQuan
Publication year - 2010
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201002077
Subject(s) - palladium , catalysis , reactivity (psychology) , selectivity , chemistry , combinatorial chemistry , surface modification , functional group , medicinal chemistry , stereochemistry , organic chemistry , medicine , alternative medicine , pathology , polymer
A balancing act : Complementary catalytic systems are described, in which the reactivity/selectivity balance in Pd II ‐catalyzed ortho ‐CH olefination can be modulated to enable sequential CH functionalization for the rapid preparation of 1,2,3‐trisubstituted arenes 1 . Additionally, a rare example of iterative CH activation, in which a newly installed functional group directs subsequent CH activation has been demonstrated ( 2 ).