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Metal Complexes as Protein Kinase Inhibitors
Author(s) -
Kunick Conrad,
Ott Ingo
Publication year - 2010
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201002062
Subject(s) - zebrafish , angiogenesis , chemistry , protein kinase a , kinase , microbiology and biotechnology , biochemistry , cancer research , biology , gene
Angiogenesis inhibition : Metal complexes are often overlooked in the development of new drugs. However, rationally designed iridium complexes with bidentate pyridocarbazole ligands have been found to act as selective protein kinase inhibitors. Experiments in zebrafish embryos revealed impressive anti‐angiogenic effects for this type of metallodrug. (Picture: tumor‐induced angiogenesis in a zebrafish embryo; red: transplanted tumor cells, green: blood vessels).