Inside Cover: Chemical Proteomics Discloses Petrosapongiolide M, an Antiinflammatory Marine Sesterterpene, as a Proteasome Inhibitor (Angew. Chem. Int. Ed. 23/2010) | Zendy

Margarucci Luigi | Zendy; Monti Maria Chiara | Zendy; Tosco Alessandra | Zendy; Riccio Raffaele | Zendy; Casapullo Agostino | Zendy

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Inside Cover: Chemical Proteomics Discloses Petrosapongiolide M, an Antiinflammatory Marine Sesterterpene, as a Proteasome Inhibitor (Angew. Chem. Int. Ed. 23/2010)

Author(s) -

Margarucci Luigi,

Monti Maria Chiara,

Tosco Alessandra,

Riccio Raffaele,

Casapullo Agostino

Publication year - 2010

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Reports

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.201002028

Subject(s) - proteasome , natural product , cover (algebra) , int , drug target , chemistry , biochemistry , engineering , computer science , mechanical engineering , operating system

Petrosaspongiolide M , a marine natural product with anti‐inflammatory properties, has an intriguing pharmacological profile. In their Communication on page 3960 ff. Casapullo and co‐workers identified the macromolecular targets of this potential drug candidate; the 20S proteasome was found to be its most important target.

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