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Inside Cover: Chemical Proteomics Discloses Petrosapongiolide M, an Antiinflammatory Marine Sesterterpene, as a Proteasome Inhibitor (Angew. Chem. Int. Ed. 23/2010)
Author(s) -
Margarucci Luigi,
Monti Maria Chiara,
Tosco Alessandra,
Riccio Raffaele,
Casapullo Agostino
Publication year - 2010
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201002028
Subject(s) - proteasome , natural product , cover (algebra) , int , drug target , chemistry , biochemistry , engineering , computer science , mechanical engineering , operating system
Petrosaspongiolide M , a marine natural product with anti‐inflammatory properties, has an intriguing pharmacological profile. In their Communication on page 3960 ff. Casapullo and co‐workers identified the macromolecular targets of this potential drug candidate; the 20S proteasome was found to be its most important target.