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Total Synthesis of Dictyodendrin A and B
Author(s) -
Okano Kentaro,
Fujiwara Hideto,
Noji Toshiharu,
Fukuyama Tohru,
Tokuyama Hidetoshi
Publication year - 2010
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201001966
Subject(s) - aryne , total synthesis , indoline , key (lock) , sequence (biology) , computer science , modular design , line (geometry) , information retrieval , stereochemistry , world wide web , chemistry , programming language , organic chemistry , mathematics , operating system , biochemistry , geometry
In‐do‐line of fire : A highly efficient total synthesis of the title compounds features a novel benzyne‐mediated one‐pot indoline formation/cross‐coupling sequence for the construction of a highly substituted key indoline intermediate. The peripheral substituents were then introduced onto the intermediate in a modular fashion to complete the total syntheses of dictyodendrin A and B.
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