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Convergence Leads to Success: Total Synthesis of the Complex Nonribosomal Peptide Polytheonamide B
Author(s) -
Ducho Christian
Publication year - 2010
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201001917
Subject(s) - peptide , nonribosomal peptide , total synthesis , chemistry , residue (chemistry) , peptide synthesis , combinatorial chemistry , ribosome , stereochemistry , organic chemistry , biochemistry , biosynthesis , rna , enzyme , gene
Beyond the ribosome : The highly cytotoxic 48 residue nonribosomal peptide polytheonamide B, proposed to act as an ion channel, was synthesized by the coupling of four building blocks. The assembly of these peptide segments required the synthesis of eight nonproteinogenic amino acids, including a unique sulfoxide. This first synthetic route towards polytheonamide B (see scheme) demonstrates the potential of state‐of‐the‐art peptide chemistry.