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Traceless Ligation of Cysteine Peptides Using Selective Deselenization
Author(s) -
Metanis Norman,
Keinan Ehud,
Dawson Philip E.
Publication year - 2010
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201001900
Subject(s) - library science , chemistry , computer science
Selective deselenization : Native chemical ligation at selenocysteine is followed by selective deselenization of the selenocysteine to alanine, in the presence of cysteine residues without protecting groups (see scheme). This selectivity is achieved by using the water‐soluble tris(2‐carboxyethyl)phosphine (TCEP) in the absence of a radical initiator.