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Catalytic Asymmetric Reductive Amination of α‐Branched Ketones
Author(s) -
Wakchaure Vijay N.,
Zhou Jian,
Hoffmann Sebastian,
List Benjamin
Publication year - 2010
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201001715
Subject(s) - reductive amination , amination , kinetic resolution , chemistry , catalysis , branching (polymer chemistry) , organic chemistry , combinatorial chemistry , enantioselective synthesis
Branching out : An organocatalytic reductive amination of α‐branched ketones using dynamic kinetic resolution is reported. The cis ‐2‐substituted cyclohexyl amines were obtained in high diastereoselectivity and enantioselectivity from the corresponding ketones.