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Inside Cover: Does Size Really Matter? The Steric Isotope Effect in a Supramolecular Host–Guest Exchange Reaction (Angew. Chem. Int. Ed. 21/2010)
Author(s) -
Mugridge Jeffrey S.,
Bergman Robert G.,
Raymond Kenneth N.
Publication year - 2010
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201001707
Subject(s) - steric effects , supramolecular chemistry , kinetic isotope effect , chemistry , deuterium , molecule , crystallography , stereochemistry , physics , organic chemistry , atomic physics
Kinetic isotope effects are observed in the guest exchange process in a supramolecular host–guest system. As reported by J. S. Mugridge, R. G. Bergman, and K. N. Raymond in their Communication on page 3635 ff., deuteration of the guest molecule results in up to an 11 % increase in the rate of guest ejection from the host cavity. The observed isotope effects are consistent with the smaller size of deuterated guest molecules, but are more fully explained by changes in guest CH/D vibrational modes at the sterically crowded transition state for guest exchange.