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Straightforward Synthesis of Ethers: Metal‐Free Reductive Coupling of Tosylhydrazones with Alcohols or Phenols
Author(s) -
Barluenga José,
TomásGamasa María,
Aznar Fernando,
Valdés Carlos
Publication year - 2010
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201001704
Subject(s) - chemistry , alkyl , alcohol , aryl , phenols , organic chemistry , phenol , combinatorial chemistry
Ethers made easy : Heating a solution containing a tosylhydrazone and either a phenol or an alcohol in the presence of K 2 CO 3 leads to the corresponding ethers (see scheme; MW=microwave, Ts=tosyl). The reaction is fairly general for the preparation of aryl alkyl and alkyl alkyl ethers, and represents a new method for the reductive etherification of carbonyl compounds.