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Highly Enantioselective Insertion of Carbenoids into NH Bonds Catalyzed by Copper(I) Complexes of Binol Derivatives
Author(s) -
Hou Zongrui,
Wang Jun,
He Peng,
Wang Jing,
Qin Bo,
Liu Xiaohua,
Lin Lili,
Feng Xiaoming
Publication year - 2010
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201001686
Subject(s) - enantioselective synthesis , copper , catalysis , chemistry , stereochemistry , combinatorial chemistry , medicinal chemistry , polymer chemistry , organic chemistry
Secondary amines do it too! Catalytic asymmetric insertion of α‐diazoesters in the NH bond of differently substituted amines has been successfully achieved (see scheme; M.S.=molecular sieves). For a wide substrate scope, excellent enantioselectivities (up to 98 % ee ) and high yields (up to 99 %) were obtained under mild reaction conditions.