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Phosphate‐Mediated Interconversion of Ribo‐ and Arabino‐ Configured Prebiotic Nucleotide Intermediates
Author(s) -
Powner Matthew W.,
Sutherland John D.
Publication year - 2010
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201001662
Subject(s) - enantiopure drug , nucleotide , stereochemistry , chemistry , prebiotic , pyrimidine , arabinose , phosphate , biochemistry , computational biology , biology , enantioselective synthesis , gene , catalysis , xylose , fermentation
Flipping stereochemistry : Inorganic phosphate catalyzes the interconversion of ribose and arabinose aminooxazolines, suggesting that the prebiotic synthesis of enantiopure pyrimidine ribonucleotides might have involved a single stereoinversion at C1′ and a double stereoinversion at C2′.