Premium
Inside Cover: Sensitive Detection of Native Proteins Using Extractive Electrospray Ionization Mass Spectrometry (Angew. Chem. Int. Ed. 17/2010)
Author(s) -
Chen Huanwen,
Yang Shuiping,
Li Ming,
Hu Bin,
Li Jianqiang,
Wang Jiang
Publication year - 2010
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201001657
Subject(s) - extractive electrospray ionization , mass spectrometry , electrospray ionization , chemistry , chromatography , ionization , electrospray , analytical chemistry (journal) , cover (algebra) , protein mass spectrometry , ion , organic chemistry , engineering , mechanical engineering
Characterization of native proteins can be undertaken with extractive electrospray ionization mass spectrometry (EESI‐MS). As H. Chen and co‐workers describe in their Communication on page 3053 ff., EESI deposits charges on native proteins, which are separated from any high electric field. This method facilitates mass spectrometry, even from raw biological samples, without significant conformational changes or reduction in activity.