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Inside Cover: In Vivo Chemistry for Pretargeted Tumor Imaging in Live Mice (Angew. Chem. Int. Ed. 19/2010)
Author(s) -
Rossin Raffaella,
Renart Verkerk Pascal,
van den Bosch Sandra M.,
Vulders Roland C. M.,
Verel Iris,
Lub Johan,
Robillard Marc S.
Publication year - 2010
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201001645
Subject(s) - tetrazine , in vivo , chemistry , bioorthogonal chemistry , cyclooctene , cover (algebra) , biophysics , click chemistry , combinatorial chemistry , biochemistry , biology , organic chemistry , catalysis , microbiology and biotechnology , mechanical engineering , engineering
Inverse‐electron‐demand Diels–Alder reactions can be performed efficiently in a living animal. In their Communication on page 3375 ff., M. S. Robillard and co‐workers report a 52 % yield in vivo between a tumor‐localized antibody carrying trans ‐cyclooctene tags and a 111 In‐labeled tetrazine probe. The rapid reaction of the chemically tagged tumors with the probe resulted in pronounced radioactivity localization in the tumor, as demonstrated by non‐invasive imaging of live mice.