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Marcus Analysis of Ambident Reactivity
Author(s) -
Breugst Martin,
Zipse Hendrik,
Guthrie J. Peter,
Mayr Herbert
Publication year - 2010
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201001574
Subject(s) - hsab theory , reactivity (psychology) , nucleophile , chemistry , computer science , computational chemistry , organic chemistry , medicine , alternative medicine , pathology , catalysis
A better approach to ambident reactivity : The principle of hard and soft acids and bases (HSAB) cannot rationalize the reactivities of even the prototypical ambident nucleophiles shown in the picture. Marcus theory, which describes activation energies by a combination of intrinsic and thermodynamic terms, is a superior alternative.