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Synthesis of Aryl Fluorides on a Solid Support and in Solution by Utilizing a Fluorinated Solvent
Author(s) -
Döbele Marion,
Vanderheiden Sylvia,
Jung Nicole,
Bräse Stefan
Publication year - 2010
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201001507
Subject(s) - solvent , aryl , chemistry , combinatorial chemistry , organic chemistry , alkyl
F for fast : The perfluorinated solvent C 6 F 14 is the key to a new variant of the Balz–Schiemann reaction for the synthesis of fluorinated arenes. Triazenes are converted into fluoroarenes under mild conditions on a support and in solution (see scheme). The method is straightforward and inexpensive, and yields previously difficult‐to‐prepare fluoroarenes in high purity.