Coherent Quenching of a Fluorophore for the Design of a Highly Sensitive In‐Stem Molecular Beacon | Zendy

Hara Yuichi | Zendy; Fujii Taiga | Zendy; Kashida Hiromu | Zendy; Sekiguchi Koji | Zendy; Liang Xingguo | Zendy; Niwa Kosuke | Zendy; Takase Tomokazu | Zendy; Yoshida Yasuko | Zendy; Asanuma Hiroyuki | Zendy

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Coherent Quenching of a Fluorophore for the Design of a Highly Sensitive In‐Stem Molecular Beacon

Author(s) -

Hara Yuichi,

Fujii Taiga,

Kashida Hiromu,

Sekiguchi Koji,

Liang Xingguo,

Niwa Kosuke,

Takase Tomokazu,

Yoshida Yasuko,

Asanuma Hiroyuki

Publication year - 2010

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.201001459

Subject(s) - fluorophore , quenching (fluorescence) , molecular beacon , scheme (mathematics) , computer science , chemistry , rational design , combinatorial chemistry , fluorescence , photochemistry , information retrieval , materials science , physics , nanotechnology , optics , mathematics , biochemistry , dna , mathematical analysis , oligonucleotide

Excitonic interaction was utilized to design a highly sensitive in‐stem molecular beacon (ISMB) in which both a fluorophore and a quencher on D ‐threoninols are incorporated as a pseudo base pair (see scheme; optimized combination with Cy3 and modified Methyl Red). Minimization of the difference between λ max of the fluorophore and quencher maximized quenching efficiency.

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