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Self‐Assembly of Thermally Responsive Amphiphilic Diblock Copolypeptides into Spherical Micellar Nanoparticles
Author(s) -
Kim Wookhyun,
Thévenot Julie,
Ibarboure Emmanuel,
Lecommandoux Sébastien,
Chaikof Elliot L.
Publication year - 2010
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201001356
Subject(s) - amphiphile , micelle , nanoparticle , materials science , chemical engineering , self assembly , polymer chemistry , nanotechnology , copolymer , chemistry , composite material , organic chemistry , polymer , aqueous solution , engineering
Stable micellar structures were synthesized containing cysteine residues at the diblock interface to stabilize micellar structure (see picture). Self‐assembly of these copolypeptides affords a new class of protein nanoparticles with potential applications in drug‐delivery and bioimaging.