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Robust Generation of Lead Compounds for Protein–Protein Interactions by Computational and MCR Chemistry: p53/Hdm2 Antagonists
Author(s) -
Czarna Anna,
Beck Barbara,
Srivastava Stuti,
Popowicz Grzegorz M.,
Wolf Siglinde,
Huang Yijun,
Bista Michal,
Holak Tad A.,
Dömling Alexander
Publication year - 2010
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201001343
Subject(s) - protein chemistry , chemistry , computational biology , computer science , lead (geology) , structural biology , combinatorial chemistry , biochemistry , biology , paleontology
The parallel discovery of multiple scaffolds useful to antagonize the cancer‐relevant protein–protein interaction p53/Hdm2 is described. The new method is based on the tightly interwoven interplay of multicomponent reaction chemistry, structural biology, computational chemistry, and high‐content NMR‐based screening.