Highly Modular Structure and Ligand Binding by Conformational Capture in a Minimalistic Riboswitch | Zendy

DuchardtFerner Elke | Zendy; Weigand Julia E. | Zendy; Ohlenschläger Oliver | Zendy; Schmidtke Sina R. | Zendy; Suess Beatrix | Zendy; Wöhnert Jens | Zendy

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Highly Modular Structure and Ligand Binding by Conformational Capture in a Minimalistic Riboswitch

Author(s) -

DuchardtFerner Elke,

Weigand Julia E.,

Ohlenschläger Oliver,

Schmidtke Sina R.,

Suess Beatrix,

Wöhnert Jens

Publication year - 2010

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.201001339

Subject(s) - riboswitch , ligand (biochemistry) , chemistry , nuclear magnetic resonance spectroscopy , stereochemistry , conformational change , rna , crystallography , biophysics , biology , biochemistry , receptor , gene , non coding rna

Be prepared : The structure of an synthetic neomycin riboswitch RNA (N1) is investigated by NMR spectroscopy. A largely disordered free structural ensemble also contains a compact conformation that resembles the ligand‐bound state thus suggesting a binding mechanism by conformational capture (see scheme, red=ligand).

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