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2‐Aminopurine Incorporation Perturbs the Dynamics and Structure of DNA
Author(s) -
Dallmann André,
Dehmel Lars,
Peters Torben,
Mügge Clemens,
Griesinger Christian,
Tuma Jennifer,
Ernsting Nikolaus P.
Publication year - 2010
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201001312
Subject(s) - dna , dynamics (music) , biophysics , helix (gastropod) , base pair , chemistry , biology , physics , biochemistry , ecology , snail , acoustics
Vive la petite différence : 2‐Aminopurine (2AP) induces small but detectable perturbations of the DNA helix. More significant are changes in the base‐pair dynamics in the vicinity of 2AP. The differences have been characterized in NMR and UV spectroscopic studies on a 13‐mer DNA double strand with either adenine (A) or 2AP in a central position.