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The AlkB Domain of Mammalian ABH8 Catalyzes Hydroxylation of 5‐Methoxycarbonylmethyluridine at the Wobble Position of tRNA
Author(s) -
Fu Ye,
Dai Qing,
Zhang Wen,
Ren Jin,
Pan Tao,
He Chuan
Publication year - 2010
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201001242
Subject(s) - medicine , chemistry
Family ties : The AlkB family of nonheme iron, α‐ketoglutarate (αKG)‐dependent dioxygenases is involved in biological processes such as DNA/RNA repair and obesity. The AlkB domain of ABH8 is shown to catalyze the hydroxylation of a modified uridine (mcm 5 U) into ( S )‐mchm 5 U at the wobble position of the anticodon stem–loop in tRNA (see scheme), thereby suggesting that this protein is a tRNA hypermodification enzyme.