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Controlled Hydrogen‐Bond Breaking in a Rotaxane by Discrete Solvation
Author(s) -
Rijs Anouk M.,
Sändig Nadja,
Blom Martine N.,
Oomens Jos,
Hannam Jeffrey S.,
Leigh David A.,
Zerbetto Francesco,
Buma Wybren J.
Publication year - 2010
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201001231
Subject(s) - rotaxane , hydrogen bond , solvation , molecule , thread (computing) , brake , threading (protein sequence) , chemistry , catenane , materials science , crystallography , supramolecular chemistry , organic chemistry , protein structure , computer science , biochemistry , metallurgy , operating system
Controlling a molecular brake : Binding interactions between the thread and the macrocycle of a [2]rotaxane can be tuned in a quasi‐continuous manner by adding hydrogen‐bond‐forming solvent molecules one at a time to an isolated [2]rotaxane molecule. Conformational changes that detach the thread from the macrocycle can be induced controllably, and the system resembles a molecular version of applying and releasing a brake.