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Probing the Kinetics of Short‐Distance Drug Release from Nanocarriers to Nanoacceptors
Author(s) -
Wang Hong,
Xu Jun,
Wang Jinghao,
Chen Tao,
Wang Yong,
Tan Yan Wen,
Su Haibin,
Chan Khai Leok,
Chen Hongyu
Publication year - 2010
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201001065
Subject(s) - nanocarriers , drug delivery , colloidal gold , drug , kinetics , nanotechnology , nanoscopic scale , nanoparticle , polymer , chemistry , materials science , biophysics , pharmacology , organic chemistry , medicine , physics , quantum mechanics , biology
Quick release : Polymer‐coated gold nanoparticles (AuNPs) are used as nanocarriers and nanoscale acceptors are used to represent proteins and lipid membranes in a model drug‐delivery system. The fluorescence of a drug is quenched in the vicinity of the AuNPs but reemerges upon its release (see picture). The critical role of nanoacceptors in facilitating drug release is demonstrated.