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A Synthetic Double Punch: Suzuki–Miyaura Cross‐Coupling Mates with CH Functionalization
Author(s) -
Knappke Christiane E. I.,
Jacobi von Wangelin Axel
Publication year - 2010
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201001028
Subject(s) - metalation , chemistry , surface modification , carbamate , combinatorial chemistry , coupling reaction , nickel , catalysis , stereochemistry , organic chemistry
Twice as good : This highlight illustrates the development of new protocols for the efficient synthesis of polysubstituted arenes. The dual role of carbamate and sulfamate substituents as directing and leaving groups has been exploited in efficient reaction sequences of directed ortho ‐metalation and chemoselective nickel‐catalyzed Suzuki–Miyaura cross‐coupling reactions (see structure).