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Rhodium‐Catalyzed Asymmetric Hydroformylation of N ‐Allylamides: Highly Enantioselective Approach to β 2 ‐Amino Aldehydes
Author(s) -
Zhang Xiaowei,
Cao Bonan,
Yu Shichao,
Zhang Xumu
Publication year - 2010
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201000955
Subject(s) - hydroformylation , enantioselective synthesis , rhodium , catalysis , allylic rearrangement , chemistry , scheme (mathematics) , organic chemistry , combinatorial chemistry , mathematics , mathematical analysis
You′re having a lahf! The asymmetric hydroformylation (AHF) of allylic compounds, catalyzed by a rhodium–yanphos complex, is a direct and concise route to β 2 ‐amino aldehydes, acids, and alcohols with excellent enantioselectivity (see scheme; TON=turnover number, acac=acetylacetonate).